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In a very the latest review, we claimed the identification and also the characterization of a new atypical opioid receptor with special unfavorable regulatory Qualities toward opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto often called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a broad-spectrum sca